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Session Schedule

Find a specific presentation in the course by navigating to the timestamp indicated below.

0:00:00
Proteomic and metabolomic perspectives in the study of PLMS/RLS
Katie L.J. Cederberg (United States)

0:20:30
Integrative proteomics and glycomics in narcolepsy: Biomarkers and mechanistic insights
Yehia Mechref (United States)

0:36:20
New insights into Kleine-Levin syndrome: Orexin and omics biomarkers
Fang Han (China)

0:52:40
Decoding the proteomic and transcriptomic landscape of restless legs syndrome
Maria Paola Mogavero (Italy)

1:10:40
Question and answer

Summary

This symposium will explore the cutting-edge advancements in the molecular understanding of sleep disorders, focusing on proteomics, metabolomics, and transcriptomics. Sleep disorders such as sleep apnea, restless legs syndrome (RLS), and rare but disabling conditions like narcolepsy and Kleine-Levin Syndrome affect millions worldwide, yet their underlying biological mechanisms remain elusive. Recent breakthroughs in proteomics and other omics approaches provide a deeper understanding of these disorders at the molecular level, offering potential biomarkers for diagnosis and targets for novel therapies.
The symposium brings together leading experts to present their latest research findings, spanning multiple sleep disorders and employing a range of high-throughput techniques to uncover disease-specific biomarkers. The presentations will emphasize how omics-based approaches can offer new insights into the pathophysiology of these conditions, with the potential to revolutionize clinical practice in sleep medicine. This symposium will provide attendees with a comprehensive view of how molecular research is reshaping our understanding of sleep disorders, with a particular focus on identifying potential disease-specific biomarkers and therapeutic targets, including for rare and complex conditions like narcolepsy and Kleine-Levin Syndrome.

Learning Objectives:

Upon completion of this CME activity, participants will be able to:
• Determine how proteomic and metabolomic techniques can reveal novel biomarkers and molecular mechanisms associated with periodic limb movements during sleep (PLMS) and restless legs syndrome (RLS)
• Explore the integration of proteomics and glycomics to identify specific biomarkers and elucidate mechanistic pathways underlying narcolepsy
• Investigate the role of orexin dysregulation and omics-based biomarker discovery in understanding the pathophysiology of Kleine-Levin Syndrome
• Analyze how proteomic and transcriptomic approaches contribute to identifying molecular signatures and potential therapeutic targets in restless legs syndrome