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Session Schedule

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0:00:00
Introduction

0:00:50
Mechanistic insights into the autoimmune hypothesis of narcolepsy: Novel cellular and animal findings
Christelle Peyron (France)

0:24:10
A European perspective on the role of immunological triggers on the development of central disorders of hypersomnolence
Jari Gool (Netherlands)

0:45:15
The role of different influenza strains on the onset of narcolepsy in the United States
Emmanuel Mignot (United States)

0:56:35
The role of upper airway infection as trigger for children narcolepsy type 1 in China
Fang Han (China)

1:13:47
Question and answer

Summary

In recent years, observations from the United States, Europe and Asia have uncovered important new insights in the immunological pathophysiology of narcolepsy type 1. More and more are we uncovering the genetic and environmental factors underlying the multiple hit hypothesis. Also, what do these discoveries mean for the ununderstood central disorders of hypersomnolence, narcolepsy type 2 and idiopathic hypersomnia? During this symposium the most recent developments will be presented and interpreted. First, Birgitte Kornum will provide an overview about what is currently known about the auto-immune basis of narcolepsy type 1. Second, Jari Gool will present new epidemiological data from the European Narcolepsy Network that suggest new potential immunological triggers for narcolepsy type 1, including other influenza strains than type A H1N1. He will also present findings that warrant future research into a possible autoimmune origin of narcolepsy type 2 and idiopathic hypersomnia. Third, Yan Han will present unique independent in-vitro data originating from the United States suggesting the very same trigger new trigger for narcolepsy type 1. Finally, Fang Han will provide the latest data from China in relationship to upper airway infections, including COVID-19, and possible onset of narcolepsy type 1.