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Session Schedule

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0:00:00
Introduction

0:03:10
Role of dopamine signaling in the amygdala in the regulation of REM sleep
Emi Hasegawa (Japan)

0:28:22
The teleological mystery of sleep — Glioneuronal mechanisms integrating sleep homeostasis and motivation
Michael Lazarus (Japan)

0:52:19
Long-range and local networks that regulate sleep-promoting ventrolateral preoptic neurons
Elda Arrigoni (United States)

1:17:10
The intersection of sleep and stress circuity: How the brain drives hyperarousal in insomnia
Patrick Fuller (United States)

Summary

Our understanding of the circuits in the brain that control sleep-wake behavior has grown considerably over the past 2 decades. It remains however unclear how the “switching” of brain circuits can occur within seconds, while the processes of accumulation/dissipation of sleep need take, typically, hours. The invited speakers will discuss their recent work in which they have identified new cellular and molecular elements of the circuits that control/regulate behavioral states, namely wake, NREM, and REM sleep. For example, Dr. Elda Arrigoni will discuss her lab’s latest findings on how wake- and sleep-promoting signals control neurons in the preoptic forebrain, in particular sleep- and wake-active neurons located in the ventrolateral preoptic area. Dr. Lazarus will discuss his research on the gating of sleep homeostasis by motivational arousal. Dr. Hasegawa will present her work on dopamine signaling in the amygdala that is critical for the transition from NREM to REM sleep and, also, may play a key role in cataplexy pathogenesis. Dr. Fuller will discuss how the brain’s arousal network(s) interact (circuitry and synaptic bases) to influence the brain’s sleep network(s) that regulate these processes, including the temporal structure, and in the context of neuropathologic dysfunction. The speakers' work reveals critical pathological mechanisms underlying sleep disorders, including the various manifestations of insomnia from objective sleeplessness to sleep misperception. With respect to diversity, our Speaker panel includes faculty from all ‘ranks’ (Associate and Professor), a balance of gender, and expertise spanning the continuum of sleep-wake control, and we hail from 4 different countries, spanning Italy to US to Germany to Japan.