Session Schedule

Find a specific presentation in the session by navigating to the timestamp indicated below.

0:00:00
Neurobiology of paradoxical sleep
Pierre-Herve Luppi (France)

0:12:10
REM-off neurons in the sublaterodorsal tegmentum (SLD) predict the onset of REM sleep
Luis de Lecea (United States)

0:23:10
New markers of REM-on neurons in the sublaterodorsal tegmenjtum (SLD) sufficient to induce REM sleep
Yu Hayashi (Japan)

0:36:56
Infraslow oscillation gates REM sleep
Anita Luthi (Switzerland)

0:50:02
Identifying makers of ultradian REM sleep timing in EEG and EMG data
Franz Weber (United States)

1:03:16
Question and answer

Summary

REM sleep duration has been associated with longevity. However, the neuronal mechanisms underlying REM sleep duration and homeostasis are practically unknown. The symposium will start with a general introduction to the neuronal circuits long known to initiate and maintain REM sleep based on experiments accumulated over 30 years (Luppi). The panel will present recent transformative work on new circuits sufficient to induce REM sleep, even from wakefulness (Hayashi), circuits that predict the onset and duration of REM sleep (de Lecea) markers in EEG and EMG that predict ultradian REM sleep timing (Weber), and circuits that are permissive of REM sleep (Luthi). New cell types and surprising connections between brainstem structures are shaping our view of REM sleep regulation and open the possibility of precise manipulation of REM sleep features. The panel will discuss how these advancements will lead to a new era in sleep intervention for pathologies such as REM behavior disorder and Parkinson's disease.