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Session Schedule

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Introduction

0:01:15
The latest knowledge on OSA pathophysiology and opportunities to advance personalized care
Danny Eckert (Australia)

0:19:53
Development of simplified OSA endotype metrics and their role in guiding targeted therapies including pharmacotherapies and beyond
Amal Osman (Australia)

0:34:45
Cohorts, data standardization, technical & measurement perspectives and the need for data sharing/collaboration to advance OSA endo-phenotyping
Scott Sands (United States)

0:54:35
Use of digital health and novel technology to advance clinical translation of OSA endo-phenotyping for personalized care
Jean-Louis Pépin (France)

1:10:40
Summary of the ATS research statement recommendations and findings
Thomas M Tolbert (United States)

1:31:15
Question and answer

Summary
The American Thoracic Society (ATS) recently commissioned an international multidisciplinary Working Group with expertise in obstructive sleep apnea (OSA) epidemiology, pathophysiology, diagnostics, and treatments to prepare an official ATS Research Statement on Translating Endo-Phenotyping of Adult Obstructive Sleep Apnea to the Clinic. The goals were to outline the rationale for clinical use, challenges, and key research priorities required to translate OSA endo-phenotyping for delivery of a more tailored approach to improve patient care and outcomes.
With this background in mind, this session will cover key aspects of the working group topics including:

The latest knowledge on OSA pathophysiology
Promising therapies targeted toward specific pathophysiological mechanisms and clinical manifestations of OSA
Measurement and big data/cohort perspectives
The use of novel technology to advance clinical translation of OSA endo-phenotyping
Overview of the working group’s findings and recommendations, which provide a road map of the opportunities and key steps required to generate the evidence necessary to translate OSA endo-phenotyping into clinical care at scale.
Topics will cover the spectrum of endo-phenotype development from discovery to translation/implementation, including technical standards for use, external validation, stability and reproducibility of measurement, establishment of clinical cutoffs/minimal clinically important differences, generalizability across diverse populations, prospective study design, and analysis of the potential impact with deployment of endo-phenotyping in clinical settings.