Session Schedule

Find a specific presentation in the session by navigating to the timestamp indicated below.

0:00:00
Shared and Unique Genetic Mechanisms Between Self-Reported or Clinical Insomnia
Hanna Ollila on behalf of Richa Saxena (United States)

0:23:34
Genetic Mechanisms in Bruxism and Clinical Implications
Tommi Strausz (United States)

0:45:26
Narcolepsy: Mechanisms and Translational Advances
Emmanuel Mignot (United States)

1:02:20
ME/CFS and Long COVID: Genetic and Omics Insights
Vilma Lammi (Finland)

Summary

Sleep disorders such as insomnia, bruxism, narcolepsy, and conditions like ME/CFS (myalgic encephalomyelitis/chronic fatigue syndrome) and Long COVID represent a diverse spectrum of neurological conditions with significant clinical and societal impacts. This symposium will explore cutting-edge genetic and omics approaches to unravel the underlying mechanisms of these disorders, bridging the gap between basic research and clinical application. Leading experts will discuss shared and distinct biological pathways, the role of molecular and genetic factors, and how these insights are shaping diagnostic and therapeutic strategies. The symposium aims to provide attendees with a deeper understanding of the translational potential of omics technologies in advancing sleep medicine.

Dr Saxena will elucidate the genetic and molecular underpinnings of insomnia, comparing self-reported and clinically diagnosed cases. Dr. Saxena will present findings from large-scale genome-wide association studies (GWAS) and integrative omics analyses, highlighting shared and unique biological pathways. The discussion will also touch upon the implications of these findings for personalized medicine.
Dr. Mignot will discuss the autoimmune and genetic mechanisms implicated in narcolepsy, focusing on the role of HLA and hypocretin pathways. He will highlight recent advances in understanding narcolepsy’s pathophysiology and their implications for diagnosis and treatment, including the predictive potential of genetic markers for identifying at-risk individuals.
Dr Strausz will discuss the genetic, neurobiological, and biomechanical factors contributing to bruxism. Dr. Strausz will also discuss the clinical implications of the novel findings in bruxism genetics including causal genetic relationship between neurological and neuropsychiatric diagnoses.
Dr Lammi will examine the genetic and neurological components and mechanisms underlying ME/CFS and Long COVID. She will discuss the role of fatigue and sleep in these conditions. Dr Lammi will summarize the recent findings from omics studies, emphasizing their implications for understanding these complex conditions and identifying potential biomarkers for clinical use.